Showing posts with label depression. Show all posts
Showing posts with label depression. Show all posts

Saturday, June 14, 2014

Depression After Brain Injury



Agency for Healthcare Research and Quality

A Guide for Patients and Their Caregivers

Is This Guide Right for Me?

Yes, if:
  • You have experienced a mild, moderate, or severe injury to your brain due to a sudden trauma. This guide is for you even if you did not see a doctor at the time of the injury.
  • A doctor or health care professional has told you that you have suffered a brain injury.
  • This guide is for you even if you have not felt depressed since your brain injury.
Where does the information for this guide come from?
The information in this guide comes from a review of many studies about traumatic brain injury and depression. The review was conducted by an independent research center and was paid for by the Agency for Healthcare Research and Quality, a research agency of the U.S. Government. You can read the full report atwww.effectivehealthcare.ahrq.gov/tbidep.cfm.

Understanding Your Condition

What is traumatic brain injury?
Traumatic brain injury (TBI) is the medical term for when your brain is injured by some force, such as:
  • A direct hit to your head by an object.
  • A fall to the ground or a hard surface.
  • A car, motorcycle, or bike crash.
  • An explosion or a blast very close to your head.
Doctors can tell whether your injury is mild, moderate, or severe based on what happened at the time of your injury (if you were knocked out, if you had trouble seeing clearly, or lost some memory) and by other tests. Around 1.5 million people who are not in the military experience some form of TBI each year in the United States. It is likely that more people are affected, because many people with mild TBI do not go to the emergency room or report their injury. Most TBI cases (75 percent) are mild.
Problems Caused by TBI
Any injury to your brain — even if it is mild — can cause problems such as headaches, ringing in your ears, mood changes, or trouble remembering or thinking for long periods of time. You may have found that your sleeping habits are different or that you feel tired more often.
Even several months or years after your brain injury, you may notice other difficulties, including depression or anxiety.
Depression and TBI
What is depression?
Depression is more than feeling sad every now and then. It is normal for someone who has had a TBI to feel sad by the problems caused by this injury. But for some people, those feelings can extend beyond normal feelings of sadness. People with depression feel sad, lack energy or feel tired, or have difficulty enjoying routine events almost daily. Other symptoms include difficulty sleeping, loss of appetite, poor attention or concentration, feelings of guilt or worthlessness, or thoughts of suicide.
How common is depression for people with TBI?
Research has found that patients with TBI are more likely to experience depression than those who have not had a brain injury.
For every 10 people who do NOT have a brain injury, approximately one person will have depression.
For every 10 people who DO have a brain injury, approximately three people will have depression.
What increases my risk of depression?
The risk of depression after a TBI increases whether the injury is mild, moderate, or severe. Researchers cannot say if age, gender, the part of the brain that was injured, or the type of injury makes depression more likely.
How soon after my injury might I become depressed?
Researchers do not know when depression is most likely to occur after TBI. Some people experience depression right after their injury, while others develop depression a year or more later. It is important to tell your doctor about any symptoms of depression you may be having even if it has been a while since your head injury. Your doctor or health care professional will ask you a series of questions or have you fill out a questionnaire or form to see if you have depression.
How can I tell if I am depressed?
There are ways to tell if you are depressed.
  • Feeling down, depressed, or sad most of the day.
  • Changes in your sleeping habits, such as sleeping poorly or sleeping more than usual.
  • Losing interest in usual activities such as favorite hobbies, time with family members, or activities with friends.
  • Increasing your use of alcohol, drugs, or tobacco.
  • Not eating as much or eating more, whether or not you are hungry.
  • Strong feelings of sadness, despair, or hopelessness.
  • Thoughts of suicide.
You may not notice some of these symptoms, but people living and working around you may see them. You may want to ask the people close to you if they notice these signs in you.
What should I do if these symptoms start to occur?
Tell your doctor or health care professional as soon as you or others around you notice any symptoms.

Understanding Your Choices

How is depression treated?
Depression is usually treated two ways:
  • Personal counseling with a special kind of health care professional. This is called “psychotherapy” (pronounced si-koh-THER-uh-pee).
    • In psychotherapy, you and a trained health care professional talk about your symptoms and how to develop ways to deal with them.
    • You might meet with your therapist weekly for several months or longer, depending on how you feel.
  • Medicines called “antidepressants” (pronounced an-tee-dee-PRESS-uhnts).
    • Several types of antidepressants are used to treat depression and anxiety.
    • You might need to take these medicines for several months or longer, depending on how you feel.
    •  
Many times, people need both psychotherapy and medicines.
Researchers do not know the specific benefits and harms or side effects of psychotherapy and antidepressants for people with TBI. However, both psychotherapy and antidepressants have helped people with depression.
Are there any side effects from antidepressants?
All antidepressants can cause side effects.
Researchers do not know if the side effects are different for people with TBI than for other people who take antidepressants. However, research found that for some people antidepressants can cause:
  • Stomach or intestinal pain and diarrhea.
  • Weight gain or weight loss.
  • Nausea and vomiting.
  • Sexual problems.
  • Trouble sleeping or sleepiness during the day.
Talk to your health care professional about the possible side effects of antidepressant medicines.
One special concern for people with TBI is how antidepressants may affect other medicines they take for their brain injury. It is important to tell your doctor or health care professional about other medicines you take.
Your health care professional can help you decide
Tell your health care professional:
It is important that you contact your health care professional when you experience:
  1. Changes in sleeping or eating habits.
  2. Frequent feelings of sadness, hopelessness, anxiety, or panic.
  3. Disinterest in your favorite activities.
  4. Thoughts about suicide.
Ask your health care professional:
Here are some questions you may want to ask your health care professional if you are going to be treated for depression or anxiety following your brain injury:
  1. How often should we check to see if I am developing depression or an anxiety disorder?
  2. How long do you think I will need psychotherapy or medications to treat these problems?
Sources
The information in this guide comes from the report Traumatic Brain Injury and Depression. It was produced by the Vanderbilt University Evidence-based Practice Center through funding by the Agency for Healthcare Research and Quality (AHRQ). Information about the side effects of antidepressants comes from the report Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Depression. It was produced by the RTI International–University of North Carolina Evidence-based Practice Center through funding by AHRQ. For a copy of either of these reports or for more information about AHRQ and the Effective Health Care Program, go to www.effectivehealthcare.ahrq.gov. Additional information for this guide came from the Medline-Plus Web site, a service of the U.S. National Library of Medicine and the National Institutes of Health. This site is available at http://www.nlm.nih.gov/medlineplus/traumaticbraininjury.html.
This summary guide was prepared by the John M. Eisenberg Center for Clinical Decisions and Communications Science at Baylor College of Medicine, Houston, TX.
From the Agency for Healthcare Research and Quality. Used with permission.www.ahrq.gov.

http://www.brainline.org/content/2011/05/depression-after-brain-injury_pageall.html
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Tuesday, April 29, 2014

Depression After Traumatic Brain Injury


Depression After Traumatic Brain Injury


What is depression?

Depression is a feeling of sadness, loss, despair or hopelessness that does not get better over time and is overwhelming enough to interfere with daily life. There is cause for concern when feeling depressed or losing interest in usual activities occurs at least several days per week and lasts for more than two weeks.
Symptoms of depression include:
  • Feeling down, sad, blue or hopeless.
  • Loss of interest or pleasure in usual activities.
  • Feeling worthless, guilty, or that you are a failure.
  • Changes in sleep or appetite.
  • Difficulty concentrating.
  • Withdrawing from others.
  • Tiredness or lack of energy.
  • Moving or speaking more slowly, or feeling restless or fidgety.
  • Thoughts of death or suicide.
Feeling sad is a normal response to the losses and changes a person faces after TBI. However, prolonged feelings of sadness or not enjoying the things you used to enjoy are often key signs of depression, especially if you also have some of the other symptoms listed above.

How common is depression after TBI?

Depression is a common problem after TBI. About half of all people with TBI are affected by depression within the first year after injury. Even more (nearly two-thirds) are affected within seven years after injury. In the general population, the rate of depression is much lower, affecting fewer than one person in 10 over a one-year period. More than half of the people with TBI who are depressed also have significant anxiety.

What causes depression after TBI?

Many different factors contribute to depression after TBI, and these vary a great deal from person to person.
  • Physical changes in the brain due to injury. Depression may result from injury to the areas of the brain that control emotions. Changes in the levels of certain natural chemicals in the brain, called neurotransmitters, can cause depression.
  • Emotional response to injury. Depression can also arise as a person struggles to adjust to temporary or lasting disability, losses or role changes within the family and society.
  • Factors unrelated to injury.Some people have a higher risk for depression due to inherited genes, personal or family history, and other influences that were present before the brain injury.
- See more at: http://www.msktc.org/tbi/factsheets/Depression-After-Traumatic-Brain-Injury#sthash.825fWy4y.dpuf
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Saturday, April 12, 2014

Medical Cannabis and Anxiety, Depression and PTSD

Dear friends, I want to share what I have learned about medical cannabis and anxiety, depression and PTSD. I am sure there are many of you that also deal with these particular issues. When I first started this medical cannabis journey I only had been told it would help with my post traumatic headaches. The most amazing surprise is what it did for all my brain trauma induced mental health issues. I had been told my brain did not make serotonin after I was injured. I had taken anti-depressants for 21 years.
I was afraid of what would happen if I went off my medications. I have anger issues and was afraid I may hurt someone! I am blessed to now say I have the best over all feeling of "well being" that I have had in all these years, thanks to medical cannabis. This was an immediate an constant response ever since. I did not realize that I had PTSD until I vaporized my first indica dominant strain and literally felt my anxiety and PTSD immediately fade! I immediately felt much less brain injured since I had always thought that my PTSD symptoms were symptoms of my brain injury itself. It was not. If you have anxiety problems a lower THC level or a 50:50 ratio of CBD to THC has been what has helped me the most. I hope and pray it helps some of YOU! 

Debbie M. Wilson
READ MORE - Medical Cannabis and Anxiety, Depression and PTSD

Wednesday, March 5, 2014

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy


Research


Wei Xie, Lun Cai, Yunhong Yu, Liang Gao, Limin Xiao, Qianchao He, Zhijun Ren andYuanzheng Liu
For all author emails, please log on.
Journal of Neuroinflammation 2014, 11:41  doi:10.1186/1742-2094-11-41
Published: 4 March 2014

Abstract (provisional)

Background

Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior.

Methods

Rats which develop chronic epilepsy following pilocarpine status epilepticus exhibited a set of interictal disorders consistent with depressive-like behavior. Changes of depressive behavior were examined by taste preference test and forced swim test; brain IL-1beta, IL-6 and IDO1 expression were quantified using real-time reverse transcriptase PCR; brain kynurenine/tryptophan and serotonin/tryptophan ratios were analyzed by liquid chromatography-mass spectrometry. Oral gavage of minocycline or subcutaneous injection of 1-methyltryptophan (1-MT) were used to inhibite IDO1 expression.

Results

We observed the induction of IL-1beta and IL-6 expression in rats with chronic TLE, which further induced the upregulation of IDO1 expression in the hippocampus. The upregulation of IDO1 subsequently increased the kynurenine/tryptophan ratio and decreased the serotonin/tryptophan ratio in the hippocampus, which contributed to epilepsy-associated depressive-like behavior. The blockade of IDO1 activation prevented the development of depressive-like behavior but failed to influence spontaneous seizures. This effect was achieved either indirectly, through the anti-inflammatory tetracycline derivative minocycline, or directly, through the IDO antagonist 1-MT, which normalizes kynurenine/tryptophan and serotonin/tryptophan ratios.

Conclusion

Brain IDO1 activity plays a key role in epileptic rats with epilepsy-associated depressive-like behavior.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.


http://www.jneuroinflammation.com/content/11/1/41/abstract
READ MORE - Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy